pharmacology

Time of Death: Diphenhydramine — A Pharmacist's Case for Abandoning a Relic of 20th-Century Medicine

Diphenhydramine has occupied American medicine for over 70 years. A pharmacologist with 30 years of clinical experience makes the case that it's time to stop prescribing out of habit and start prescribing based on evidence.

Volume 1, Issue 2, April 2026

Asundexian for Secondary Stroke Prevention OCEANIC-STROKE — A Three-Lens Critical Appraisal

OCEANIC-STROKE met its primary endpoint with a 26% relative reduction in ischemic stroke and no excess major bleeding — but the prespecified hierarchy broke at the 90-day endpoint. A statistician, a neurologist, and a researcher walk into a journal club. Here's what they each see.

Beyond Weight Loss: Reading the GLP-1 Side Effect Profile in Real Numbers A field guide for clinicians who are tired of being shown hazard ratios without denominators.

The Aspiration Anaerobe Myth What actually colonizes the aerodigestive tract — and why reflexive Zosyn for “possible aspiration” fails basic microbiology

Flecainide After PCI: 35 Years After CAST, Is It Time to Reconsider Class Ic Antiarrhythmics in Coronary Artery Disease?

PharmaCompass InPHARMation is for educational purposes only and does not constitute medical advice. Always verify clinical information before applying to patient care. Full Disclaimer | © 2026 PharmaCompass Education, LLC

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Asundexian for Secondary Stroke Prevention OCEANIC-STROKE — A Three-Lens Critical Appraisal

Beyond Weight Loss: Reading the GLP-1 Side Effect Profile in Real Numbers A field guide for clinicians who are tired of being shown hazard ratios without denominators.

The Aspiration Anaerobe Myth What actually colonizes the aerodigestive tract — and why reflexive Zosyn for “possible aspiration” fails basic microbiology

Flecainide After PCI: 35 Years After CAST, Is It Time to Reconsider Class Ic Antiarrhythmics in Coronary Artery Disease?